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01 July 2017

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Mary Straus

Christie, I'm so glad this new drug is working for Tim. I wish I had known about it when my Piglet developed generalized anxiety disorder.

I tried to find information about why the usage is so limited. I found the FDA approval here:
https://www.fda.gov/downloads/AnimalVeterinary/Product/ApprovedAnimalDrugProducts/FOIADrugSummaries%2F/UCM475135.pdf

This product has previously been approved for use IM and IV as a pre-anestheic, and for sedation/analgesia, which didn't require any long-term testing. I suspect the reason they limit the dosing to 10 hours is simply because it hasn't been tested for longer periods, not because they know it's dangerous.

In section III of the FDA approval, Target Animal Safety, they gave this drug IV and IM at doses of 4x, 12x and 20x the recommended dosage. This amount was given once daily for three consecutive days with no serious adverse events. Note that the maximum concentration occurs about the same time for IM as it does for the sub-mucosal gel (https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=8113cc85-cd1e-4edc-b933-51bdbd1d8b64&type=display). Also see https://www.zoetisus.com/products/cats/dexdomitor/doc/Dexdomitor-Dosing-Chart-Canine.PDF for more details.

If this were my dog, I think I'd take the risk and continue to give it for more than five doses if needed during something like a long-lasting thunderstorm, as long as his heart rate and breathing are normal.

I don't care if you post this as a comment or not, just wanted to pass along what I had found.

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